Explanation Phenytoin has been associated with IUGR as w | 👼Pediatrics. Books,Videos, MCQs...

Explanation





Phenytoin has been associated with IUGR as well as other congenital anomalies. IUGR is associated with medical conditions that interfere with the circulation and efficiency ofthe placenta, with the development or growth of the fetus, or with the general health and nutrition of the mother. IUGR is often classifiedas reduced growth that is symmetric (head circumference, length, and weight equally affected) or asymmetric (with relative sparing of head growth). Symmetric IUGR often has an earlier onset and is associated with diseases that seriously affect fetal cell number, such as conditions with chromosomal, genetic, malformation, teratogenic, infectious, or severe maternal hypertensive etiologies. Asymmetric IUGR is often of late onset and is associated with poor maternal nutrition or with late onsetor exacerbation of maternal vascular disease(preeclampsia, chronic hypertension). Other
drugs such as narcotics, alcohol, cigarettes, cocaine, and antimetabolites are commonly a cause of IUGR